Decrypting the chaperone code
نویسندگان
چکیده
منابع مشابه
Chemical ubiquitination for decrypting a cellular code
The modification of proteins with ubiquitin (Ub) is an important regulator of eukaryotic biology and deleterious perturbation of this process is widely linked to the onset of various diseases. The regulatory capacity of the Ub signal is high and, in part, arises from the capability of Ub to be enzymatically polymerised to form polyubiquitin (polyUb) chains of eight different linkage types. Thes...
متن کاملThe Colossus of ubiquitylation: decrypting a cellular code.
Ubiquitylation is an essential posttranslational modification that can regulate the stability, activity, and localization of thousands of proteins. The reversible attachment of ubiquitin as well as interpretation of the ubiquitin signal depends on dynamic protein networks that are challenging to analyze. In this perspective, we discuss tools of the trade that have recently been developed to dis...
متن کاملAndrea Ventura: Decrypting noncoding RNAs
Ventura explores the biological functions of noncoding RNAs in cancer and development.
متن کاملDecrypting neuronal codes
The fundamental unit of the nervous system, the neuron, is now better known thanks to advances in cellular and molecular biology and in genetics. To decrypt neuronal codes underlying higher cognitive functions such as perception, attention, movement, learning, memory, language and even thought, is the main goal of research in neuroscience. This goal can only be reached thanks to a multidiscipli...
متن کاملDecrypting the role of Cripto in tumorigenesis.
The cell-surface associated molecule Cripto is overexpressed in a wide range of epithelial cancers, yet little is known about potential mechanisms by which Cripto expression might enhance tumorigenesis. A new study reveals that binding of Cripto to the TGF-beta ligand Activin B can block Activin B-mediated suppression of cell proliferation. Furthermore, this study also demonstrates that antibod...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2021
ISSN: 0021-9258
DOI: 10.1016/j.jbc.2021.100293